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Karyopharm Therapeutics

1.62

-0.0700-4.14%

Pre-market: 1.650.0300+1.85%04:00 EDT

Volume:800.95K

Turnover:1.30M

Market Cap:36.71M

PE:-0.12

High:1.68

Open:1.68

Low:1.60

Close:1.69

52wk High:10.99

52wk Low:1.60

Shares:22.66M

Float Shares:15.77M

Volume Ratio:0.90

T/O Rate:5.08%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-13.0816

EPS(LYR):-17.9300

ROE:-891.05%

ROA:-47.61%

PB:-0.11

PE(LYR):-0.09

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Overview Company News Filings

Karyopharm Therapeutics Price Target Raised to $16.00/Share From $8.00 by Piper Sandler

Karyopharm price target raised to $16 from $8 at Piper Sandler

U.S. RESEARCH ROUNDUP-East West Bancorp, Reliance, S&P Global

Karyopharm Therapeutics Inc : Piper Sandler Raises Target Price to $16 From $8

THOMSON REUTERS

Karyopharm Phase 3 SENTRY myelofibrosis trial results set for ASCO late-breaking oral presentation

Karyopharm publishes corporate presentation highlighting Phase 3 selinexor readouts in myelofibrosis

RBC Capital Adjusts Karyopharm Therapeutics PT to $16 From $23, Maintains Outperform Rating

MT Newswires Live

Karyopharm Therapeutics Price Target Cut to $8.00/Share From $12.00 by Piper Sandler

Karyopharm Therapeutics Inc : Piper Sandler Cuts Target Price to $8 From $12

THOMSON REUTERS

Karyopharm Therapeutics sells 1,030,354 shares at $6.785; gross proceeds rise to about $30 million in RA Capital private placement

BUZZ-Street View: Karyopharm's cancer drug trial results limit regulatory odds

Karyopharm Therapeutics Is Maintained at Buy by HC Wainwright & Co.

Sector Update: Health Care Stocks Advance Late Afternoon

MT Newswires Live

Karyopharm Therapeutics Falls As Pivotal Trial Hits Spleen Goal But Misses Symptom Mark

Sector Update: Health Care Stocks Mixed Pre-Bell Tuesday

MT Newswires Live

Karyopharm Therapeutics Shares Reverse Course; NOW Down 10% Premarket

THOMSON REUTERS

Karyopharm Therapeutics Shares up 16% Premarket After Co's Blood Cancer Drug Meets One of Two Main Goals in Late‑Stage Study

THOMSON REUTERS

Karyopharm Therapeutics' blood cancer drug meets one of two main goals in study

Karyopharm’s Phase 3 SENTRY trial meets first co-primary endpoint

Karyopharm prices USD 30 million private placement with RA Capital

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Overweight rating on the shares. The firm notes Karyo...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/karyopharm-price-target-raised-to-16-from-8-at-piper-sandler-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/karyopharm-price-target-raised-to-16-from-8-at-piper-sandler-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["KPTI","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2630366152","title":"U.S. RESEARCH ROUNDUP-East West Bancorp, Reliance, S&P Global","url":"https://stock-news.laohu8.com/highlight/detail?id=2630366152","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2630366152?lang=en_us&edition=fundamental","pubTime":"2026-04-27 16:41","pubTimestamp":1777279308,"startTime":"0","endTime":"0","summary":"U.S. RESEARCH ROUNDUP-East West Bancorp, Reliance, S&P GlobalApril 27 (Reuters) - Wall Street securities analysts revised their ratings and price targets on several U.S.-listed companies, including Ea","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260427:nL8N41A0G8:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["GL","AMAL","PFG","KPTI","GB00B4LPDJ14.GBP","RS","DLR","CSGP","FRDU","HMH","IT","NSC","LMT","PNFP","PG","FRDD","LU1941712264.USD","BANR","EQIX","HAL","KNSL","PFBC","LBRT","ABCB","BK4574","CHE","F","BKR","QSR","SPGI","SLB","NBHC","CPB","EWBC","HCA","BK4211","GNRC","HIG","BX","MATX","DOW","NOC","CHTR","LMTS","GM","GE","LMTL","IDXX"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2630568503","title":"Karyopharm Therapeutics Inc : Piper Sandler Raises Target Price to $16 From $8","url":"https://stock-news.laohu8.com/highlight/detail?id=2630568503","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2630568503?lang=en_us&edition=fundamental","pubTime":"2026-04-27 11:08","pubTimestamp":1777259309,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260427:nFWN418007:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4139","KPTI"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2629030791","title":"Karyopharm Phase 3 SENTRY myelofibrosis trial results set for ASCO late-breaking oral presentation","url":"https://stock-news.laohu8.com/highlight/detail?id=2629030791","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2629030791?lang=en_us&edition=fundamental","pubTime":"2026-04-21 22:33","pubTimestamp":1776782020,"startTime":"0","endTime":"0","summary":"Karyopharm flagged Phase 3 SENTRY trial results for a late-breaking oral presentation at ASCO 2026.Data have not yet been presented; ASCO scheduled abstract release for June 2, 2026, ahead of presentation later that morning.SENTRY tested once-weekly selinexor with ruxolitinib versus placebo with ruxolitinib in JAK inhibitor-nave myelofibrosis.Study focused on reducing spleen enlargement, easing symptom burden.ASCO slot positions selinexor-ruxolitinib combination as a potential differentiated first-line option in myelofibrosis, a market currently dominated by JAK inhibitors.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260421:nNDL4tZ1FC:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","KPTI"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2627292239","title":"Karyopharm publishes corporate presentation highlighting Phase 3 selinexor readouts in myelofibrosis","url":"https://stock-news.laohu8.com/highlight/detail?id=2627292239","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2627292239?lang=en_us&edition=fundamental","pubTime":"2026-04-16 19:22","pubTimestamp":1776338536,"startTime":"0","endTime":"0","summary":"Karyopharm highlighted Phase 3 SENTRY topline data in JAK inhibitor-nave myelofibrosis showing selinexor with ruxolitinib met spleen volume reduction endpoint at week 24.SVR35 at week 24 was 49.8%  for selinexor-ruxolitinib versus 28%  for placebo-ruxolitinib; one-sided p<0.0001.Symptom endpoint at week 24 missed statistical significance, with adjusted mean difference 0.97; one-sided p=0.8246.Overall survival showed a nominal signal with hazard ratio 0.43; one-sided p=0.0222 at data cutoff 2026-02-20.Company flagged mid-2026 topline data timing for Phase 3 XPORT-EC-042 trial of selinexor in TP53 wild-type endometrial cancer.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Karyopharm Therapeutics Inc. published the original content used ","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260416:nNDLLYFMC:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["KPTI","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2625533199","title":"RBC Capital Adjusts Karyopharm Therapeutics PT to $16 From $23, Maintains Outperform Rating","url":"https://stock-news.laohu8.com/highlight/detail?id=2625533199","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2625533199?lang=en_us&edition=fundamental","pubTime":"2026-04-07 20:48","pubTimestamp":1775566104,"startTime":"0","endTime":"0","summary":"Karyopharm Therapeutics (KPTI) has an average rating of Buy and mean price target of $12.86, according to analysts polled by FactSet.(MT Newswires covers equity, commodity and economic research from m","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["KPTI"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2623233423","title":"Karyopharm Therapeutics Price Target Cut to $8.00/Share From $12.00 by Piper Sandler","url":"https://stock-news.laohu8.com/highlight/detail?id=2623233423","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2623233423?lang=en_us&edition=fundamental","pubTime":"2026-03-31 02:05","pubTimestamp":1774893900,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/KPTI/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  March 30, 2026 14:05 ET (18:05 GMT)","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["KPTI"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2623539809","title":"Karyopharm Therapeutics Inc : Piper Sandler Cuts Target Price to $8 From $12","url":"https://stock-news.laohu8.com/highlight/detail?id=2623539809","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2623539809?lang=en_us&edition=fundamental","pubTime":"2026-03-30 12:21","pubTimestamp":1774844501,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260330:nFWN40F0AU:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4139","KPTI"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2622826772","title":"Karyopharm Therapeutics sells 1,030,354 shares at $6.785; gross proceeds rise to about $30 million in RA Capital private placement","url":"https://stock-news.laohu8.com/highlight/detail?id=2622826772","media":"Reuters","labels":["shareholding"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2622826772?lang=en_us&edition=fundamental","pubTime":"2026-03-27 20:05","pubTimestamp":1774613130,"startTime":"0","endTime":"0","summary":"Karyopharm Therapeutics sells 1,030,354 shares at $6.785; gross proceeds rise to about $30 million in RA Capital private placement. The deal also included pre-funded warrants to buy up to 3,391,164 shares at USD 6.78 per warrant.Accompanying warrants cover 4,421,518 shares with an exercise price of USD 10.00 per share.The private placement closed March 26, 2026 and generated gross proceeds of about USD 30.0 million.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Karyopharm Therapeutics Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on March 27, 2026, and is solely responsible for the i","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260327:nNDL4JyTgs:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"shareholding","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","KPTI"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2622807846","title":"BUZZ-Street View: Karyopharm's cancer drug trial results limit regulatory odds","url":"https://stock-news.laohu8.com/highlight/detail?id=2622807846","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2622807846?lang=en_us&edition=fundamental","pubTime":"2026-03-25 19:49","pubTimestamp":1774439351,"startTime":"0","endTime":"0","summary":"BUZZ-Street View: Karyopharm's cancer drug trial results limit regulatory odds** Karyopharm Therapeutics KPTI.O said on Tuesday its therapy led to significant reduction in spleen size in a late-stage study of patients with myelofibrosis, a rare blood cancer, meeting only one of its two main goals** The drug combination failed to meet the study's second main goal of statistically significant symptom improvement** At least two analysts lowered PT on the company MIXED RESULTS DIM CHANCE OF APPROVAL ** Cantor Fitzgerald  says the likelihood of FDA approval is minimal, given the regulatory precedent of placing significant importance on showing clear symptom improvement ** H.C. Wainwright  says missing the symptom goal weakens KPTI's path with regulators, noting other myelofibrosis drugs with similar results were not taken forward, though early survival data could still provide support** RBC Capital Markets  says \"the data is clearly imperfect, but between spleen, survival, and hints of dise","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260325:nL4N40D0V3:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["KPTI","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2622027831","title":"Karyopharm Therapeutics Is Maintained at Buy by HC Wainwright & Co.","url":"https://stock-news.laohu8.com/highlight/detail?id=2622027831","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2622027831?lang=en_us&edition=fundamental","pubTime":"2026-03-25 18:41","pubTimestamp":1774435260,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/KPTI/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  March 25, 2026 06:41 ET (10:41 GMT)","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["KPTI"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2622018994","title":"Sector Update: Health Care Stocks Advance Late Afternoon","url":"https://stock-news.laohu8.com/highlight/detail?id=2622018994","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2622018994?lang=en_us&edition=fundamental","pubTime":"2026-03-25 03:50","pubTimestamp":1774381826,"startTime":"0","endTime":"0","summary":"Health care stocks rose late Tuesday afternoon, with the NYSE Health Care Index adding 0.4% and the State Street Health Care Select Sector SPDR ETF  up 0.2%.The iShares Biotechnology ETF  shed 0.4%.In corporate news, CVS Health  has reached a proposed settlement with the Federal Trade Commission over insulin pricing, Reuters reported, citing the company. The company's pharmacy benefit management unit, Caremark, has focused on lowering prescription drug costs, CVS said, adding that the settlement is expected to be finalized in the coming weeks, with final terms still pending, the report said. CVS shares rose 2.5%.ImmunityBio  shares dropped 21% after the US Food and Drug Administration issued a warning letter citing \"misleading\" promotional materials for its bladder cancer drug Anktiva.Gilead Sciences  has agreed to acquire autoimmune disease therapy developer Ouro Medicines for up to $2.18 billion, while the biopharmaceutical firm is in collaboration talks with Galapagos  on the 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Therapeutics Falls As Pivotal Trial Hits Spleen Goal But Misses Symptom Mark","url":"https://stock-news.laohu8.com/highlight/detail?id=2622909473","media":"Benzinga","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2622909473?lang=en_us&edition=fundamental","pubTime":"2026-03-25 01:20","pubTimestamp":1774372800,"startTime":"0","endTime":"0","summary":"Karyopharm Therapeutics Inc.  shares are down on Tuesday as the company reported mixed results from its Phase 3 SENTRY trial for myelofibrosis.Myelofibrosis is a rare, chronic blood cancer  where bone marrow is replaced by scar tissue, disrupting blood cell production.The SENTRY trial met its first co-primary endpoint, showing significant improvement in spleen volume reduction for patients treated with selinexor plus ruxolitinib.The trial showed statistically significant improvement in spleen volume reduction of 35% or more  for patients treated with the combination of selinexor plus ruxolitinib.In addition, the trial demonstrated a promising overall survival signal, with a greater than 50% reduction in the risk of death compared to ruxolitinib alone.50% of patients who received the combination of selinexor plus ruxolitinib achieved a statistically significant improvement in SVR35 at week 24 compared to 28% of patients who received ruxolitinib alone.Patients on the combination achieved","market":"sh","thumbnail":"https://cdn.benzinga.com/files/images/story/2026/03/24/Acute-Myeloid-Leukemia-Is-A-Subtype-Of-B.jpeg?optimize=medium&dpr=2&auto=webp&width=630","type":0,"news_type":0,"thumbnails":["https://cdn.benzinga.com/files/images/story/2026/03/24/Acute-Myeloid-Leukemia-Is-A-Subtype-Of-B.jpeg?optimize=medium&dpr=2&auto=webp&width=630"],"rights":{"source":"benzinga_hot_news","url":"https://www.benzinga.com/news/health-care/26/03/51439552/karyopharm-therapeutics-falls-as-pivotal-trial-hits-spleen-goal-but-misses-symptom-mark","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.benzinga.com/news/health-care/26/03/51439552/karyopharm-therapeutics-falls-as-pivotal-trial-hits-spleen-goal-but-misses-symptom-mark","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"benzinga_hot_news","symbols":["BK4139","KPTI"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2621060978","title":"Sector Update: Health Care Stocks Mixed Pre-Bell Tuesday","url":"https://stock-news.laohu8.com/highlight/detail?id=2621060978","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2621060978?lang=en_us&edition=fundamental","pubTime":"2026-03-24 21:19","pubTimestamp":1774358371,"startTime":"0","endTime":"0","summary":"Health care stocks were mixed pre-bell Tuesday, with the State Street Health Care Select Sector SPDR ETF (XLV) down 0.2% and the iShares Biotechnology ETF (IBB) slightly higher.Galapagos (GLPG) said 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