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SPYRE THERAPEUTICS INC

88.71

+1.782.05%

Pre-market: 89.150.4400+0.50%06:08 EDT

Volume:902.46K

Turnover:79.43M

Market Cap:7.82B

PE:-44.14

High:88.72

Open:85.56

Low:85.26

Close:86.93

52wk High:110.18

52wk Low:14.51

Shares:88.17M

Float Shares:80.98M

Volume Ratio:0.82

T/O Rate:1.11%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-2.0100

EPS(LYR):-1.9755

ROE:-22.98%

ROA:-19.81%

PB:8.19

PE(LYR):-44.91

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Overview Company News Filings

Spyre Therapeutics files automatic mixed securities shelf

Spyre Therapeutics Files for Mixed Shelf; Size not Disclosed - Filing

THOMSON REUTERS

Movement Alert｜Spyre Therapeutics Falls 5.04% in Pre-Market Trading, Director Share Sale Continues to Pressure Stock

Spyre Therapeutics Shares Fall After Director Sells $2 Million in Stock

MT Newswires Live

Movement Alert｜Spyre Therapeutics Falls 14.76% in Regular Trading, Trading at $85.98

Movement Alert｜SPYRE THERAPEUTICS Falls 10.83% in Pre-Market Trading, Trading at $86.54

Spyre Therapeutics director Michael Thomas Henderson disposes of 20,000 common shares for $2 million

Movement Alert｜SPYRE THERAPEUTICS Overnight Decline 7.91%, Trading at $89.37

Movement Alert｜Spyre Therapeutics Rises 8.19% in After-Hours Trading, Trading at $105.0

Spyre Therapeutics : Deutsche Bank Raises Target Price to $135 From $115

THOMSON REUTERS

Spyre Therapeutics (SYRE) Is Up 16.5% After Strong Phase 2 SKYLINE Data in Ulcerative Colitis

Simply Wall St.

Analysts Offer Insights on Healthcare Companies: Spyre Therapeutics (SYRE) and Tyra Bioscience (TYRA)

Spyre says bowel disease drug cuts inflammation in mid-stage trial

Spyre Therapeutics announces SKYLINE trial achieves primary endpoint

Spyre says SPY002 hits primary endpoint in Phase 2 SKYLINE ulcerative colitis trial Part A induction data

Spyre Therapeutics - Spy002 Meets Primary Endpoint With 10.7-Point Rhi Reduction at Week 12

THOMSON REUTERS

Spyre Announces Potential Best-in-Class Spy002 (Anti-Tl1a) Part a Induction Results From Skyline Trial in Moderate-to-Severe Ulcerative Colitis Patients

THOMSON REUTERS

Spyre Therapeutics - Spy002 Well Tolerated With Safety Profile Consistent With Tl1a Class

THOMSON REUTERS

Spyre Therapeutics - Spy002 Achieves 33% Clinical Remission and 42% Endoscopic Improvement at Week 12

THOMSON REUTERS

Spyre Therapeutics - Twenty Subjects Had Treatment-Emergent Adverse Events; Two Serious, None Drug-Related

THOMSON REUTERS

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While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Spyre Therapeutics Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on June 23, 2026, and is solely responsible for the information contained therein.","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260624:nNDLc1TQ3B:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":"Spyre Therapeutics director Michael Thomas Henderson disposes of 20,000 common shares for $2 million","news_tag":"insiderTrades","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","SYRE"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"1104429755","title":"Movement 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